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Figure 3
Comparison of 3TR binding sites in the lateral channel of the E316F (a), V536W (b) and H246W (c) variants superposed onto the complex of CATPO with 3TR. The corresponding 2FoFc electron density, contoured at 0.7 r.m.s.d., is shown for the three cases as a blue mesh. Changes in solvent organization are evident among the structures. Trp246 has two alternate conformations (Fig. 4[link]).

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
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