Figure 3
Comparison of 3TR binding sites in the lateral channel of the E316F (a), V536W (b) and H246W (c) variants superposed onto the complex of CATPO with 3TR. The corresponding 2Fo − Fc electron density, contoured at 0.7 r.m.s.d., is shown for the three cases as a blue mesh. Changes in solvent organization are evident among the structures. Trp246 has two alternate conformations (Fig. 4). |