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Figure 4
Main and lateral channel solvent in CATPO–3TR (a) and the E316F (b), H246W (c) and V536W (d) variants. The corresponding electron densities are shown for the four cases. Possible hydrogen-bond interactions are shown as dashed lines. Lys312, Ile313 and Ile314 in the lateral channel were removed for clarity. Mutated residues are shown in red and the ligand 3TR in purple. The inset in (c) shows the two alternate conformations of Trp246 face on with density. 2FoFc electron density is shown as a blue mesh contoured at 0.7 r.m.s.d.. The channels are shown as transparent surfaces in Supplementary Fig. S2.

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ISSN: 2059-7983
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