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Figure 1
Sequence alignment of ISG15s from selected species. Alignment of the ISG15s from vesper bat (M. davidii; accession No. ELK23605.1), Brandt's bat (M. brandtii; accession No. XM_005871298.2), little brown bat (M. lucifugus; accession No. XP_014306702.1), large flying fox (Pteropus vampyrus; accession No. XM_011386042.2), Chinese horseshoe bat (Rhinolophus sinicus; accession No. XP_019567580.1), Egyptian fruit bat (Rousettus aegyptiacus; accession No. XP_015999857.1), great roundleaf bat (Hipposideros armiger; accession No. XP_019514054.1), vampire bat (Desmodus rotundus; accession No. XP_024410591.1), sheep (Ovis aries; accession No. AF152103.1), human (H. sapiens; accession No. AAH09507.1), northern tree shrew (Tupaia belangeri; accession No. AFH66859.1) and mouse (Mus musculus; accession No. AAB02697.1). Similarity and alignment calculations were performed using ClustalW. Residues involved in intradomain orientation are denoted in colored boxes (blue for bISG15, green for hISG15, pink for mISG15 and red for the negative patch in bISG15). The mutagenesis site is indicated by a red asterisk. The hinge region between the N-terminal domain and the C-­terminal domain is represented by a red dashed line. The secondary-structure elements in bISG15 are shown above the alignments as predicted by DSSP.

Journal logoSTRUCTURAL
ISSN: 2059-7983
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