Figure 6
A complex network of coupled conformational heterogeneity. A network of alternative conformations in a cryogenic structure of catalase (PDB entry 1gwe; Murshudov et al., 2002) with diverse properties. Multiple phenomena define the network: van der Waals interactions (blue dots and line segments) between side chains, a hydrogen bond (dotted green line) through a partial-occupancy water (brown), coupling through the locally mobile backbone (black) and perhaps electrostatic forces between the Lys (green) and nearby polar residues (Glu in blue, Asp in yellow and Ser in purple). This image was obtained using KiNG (Chen et al., 2009). |