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Figure 4
(a, b, c) Schematics of strategies to improve the hit rate in fixed-target serial data collection. (a) Linewise or raster scanning of randomly placed crystals. (b) Linewise scanning of pre-positioned crystals. (c) Targeted scanning of prelocated, randomly placed crystals. (d, e, f) Examples of solid supports. (d) Silicon chip with pre-positioned CPV18 virus crystals in holes, reproduced from Roedig et al. (2017BB90) with permission from Springer Nature. Copyright (2017). (e) Silicon chip with myoglobin crystals pre-positioned in well shaped features, reproduced from Oghbaey et al. (2016BB78). (f) UV microscopy image of a multi-crystal holder in the laboratory at room temperature (left) and a video-microscope view of the holder at 100 K before data collection on the MFX station at LCLS (right). The reference points are shown in red; crystal locations to be exposed are shown as yellow circles. The side dimension of the holder is 2.8 mm. (g) SMB in situ crystallization plate filled with grid sample-holder assemblies (Baxter et al., 2016BB6). The larger port holes are 0.4 mm and the length of the holder is 15.5 mm.

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ISSN: 2059-7983
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