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Figure 6
Accessibility of the SF4 pocket in the hRab27aMut(GppNHp) crystals. (a) The interaction between hRab27a (green) and the hSlp2a Rab-binding domain (cyan). The SF4 pocket (red), comprised of the α3/β5 loop and the α5 helix, interacts with the WF motif (yellow) of hSlp2a. (b) The SF4 pocket is well defined in the structure of the hRab27aMut(GppNHp) crystals. (c) The pocket is not occluded by neighbouring molecules (shown in surface representation) and all copies in the asymmetric unit are accessible for ligand-interaction studies.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 75| Part 3| March 2019| Pages 342-353
https://doi.org/10.1107/S2059798318017825
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