issue contents

Journal logoSTRUCTURAL
ISSN: 2059-7983

May 2019 issue

Highlighted illustration

Cover illustration: The crystal structure of a transcriptional regulator's interaction with DNA displayed on an abstract depiction of the underlying data.



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Installation of the EIGER X 1M detector onto an electron microscope and system calibration for data collection turns a transmission electron microscope into an electron diffraction instrument. Data can be collected and processed with a throughput that meets the requirements of a modern X-ray facility. The setup described here offers access to single-crystal structure determination from microcrystalline powder when large single crystals cannot be produced.

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The study of coat protein assemblies on membranes by cryo-electron tomography and subtomogram averaging is discussed, outlining the methodological advancements that enabled the gain of crucial structural insight.

research papers

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Phosphomannose isomerase is a zinc-dependent enzyme involved in reversible isomerization of mannose 6-phosphate and fructose 6-phosphate. Based on extensive site-directed mutagenesis, structural and biochemical studies on phosphomannose isomerase from Salmonella typhimurium, zinc ions were found to be indispensable for substrate binding and the catalytic base was identified as Lys86.

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The crystal structure of the WH1 domain of the eukaryotic replication initiator protein (Rep) MSBI1.176 in the dimeric form has been determined to 1.53 Å resolution and shows a number of structural similarities to and differences from other known prokaryotic Reps.

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This paper describes some statistical tools for analyses of macromolecular B values.

book reviews


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Nobel Prize winner Sir Aaron Klug is remembered.
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