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Figure 5
Amino-acid sequence alignment of MSBI1.176 (LK931491.1) and RepA (PDB entry 1hkq) using ClustalW (Genetyx); the figure was generated using ESPript (Robert & Gouet, 2014BB31) with slight modifications. Secondary-structural elements are shown and were confirmed from the crystal structure. Identical and homologous residues are highlighted on a red background and as red letters, respectively. Presumably, a DNA molecule would interact along the dimeric interface and possibly with six basic residues in this region, i.e. Lys69 (α4), Lys73 (α4), Arg78, Lys85 (β2), Arg90 (β3) and Arg96. The basic amino-acid residues of RepA that are suggested to participate in DNA interaction are marked with green triangles and the equivalent residues in MSBI1.176 WH1 are marked with blue triangles.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 75| Part 5| May 2019| Pages 498-504
https://doi.org/10.1107/S2059798319003991
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