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![[Figure 1]](cb5114fig1mag.jpg)
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Figure 1
Schematic representation of the reaction catalyzed by CMP-sialic acid synthetase (CMAS). In the presence of Mg2+, CMAS catalyzes nucleophilic attack by the anomeric O atom of β-Neu5Ac on the α-phosphate of CTP, forming CMP-sialic acid and pyrophosphate (PPi). The natural sialic acid derivatives Neu5Ac and Neu5Gc with various substitutions at the C5 position (R) are shown. This figure is adapted from Sellmeier et al. (2015  ). |
![[Figure 1]](cb5114fig1.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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