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Figure 8
Schematic showing a simplified view of error versus structural states and why the initial condition (black circle), which will be near the average structure (dashed line), tends to result in a refinement where the state is defined by T0 = 1/2 because the T0 = 1/2 state will be slightly broader and slightly shallower than the T0 = 0 state, resulting in a gradient pointing towards the T0 = 1/2 state. Here, error could be any metric that is used to measure the difference between the observed data and the model.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 75| Part 9| September 2019| Pages 852-860
https://doi.org/10.1107/S2059798319011082
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