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![[Figure 4]](jb5013fig4mag.jpg)
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Figure 4
The soaked structure of an indole acid inhibitor binding to the Mcl-1–scFv complex (PDB entry 6qb4). (a) Ribbon representation of the whole complex, with Mcl-1 (light grey) bound by the scFv (dark grey) and the inhibitor (orange). A surface representation is displayed around the ligand-binding site. (b) Detailed view of the inhibitor in the BH3 binding site, showing the critical salt-bridge interaction between the indole acid group and Arg263 and the deep hydrophobic pocket that accommodates the tetrahydronaphthyl anchor. (c) Overlay showing the structural similarity between the Mcl-1–scFv complex and published structures with analogous inhibitors. Green, PDB entry 3wix co-crystallized with Mcl-1 (Tanaka et al., 2013  ); dark red, PDB entry 4wmu co-crystallized using an Mcl-1-MBP fusion system (Clifton et al., 2015); orange, Mcl-1–scFv crystals soaked with inhibitor. |
![[Figure 4]](jb5013fig4.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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