|
Figure 1
Structure of P46. (a) Cartoon representation of P46. The N-domain is depicted in red (Ala45–Val153) and pale yellow (Asp343–Val401), while the hinge is shown in blue (consisting of three stretches: Ile339-Tyr-Lys-Pro, Ser154-Phe-Asp-Asn and Ser402-Pro-Val-Ile-Val) and the C-domain is shown in grey (Glu158–Thr338 and Thr407–Asp412). (b) Stereoview showing the (Fo − Fc) OMIT map of maltose (in green) at 3σ. (c) Stereoview showing the (Fo − Fc) OMIT map of xylose (in green) at 3σ corresponding to the structure at 3.5 Å resolution of the complex between P46 and FabP46. The binding site is located in the cleft between the N- and C-domains of P46. In (b) and (c) the corresponding (2Fo − Fc) electron-density maps are also shown (in blue). |