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![[Figure 2]](jb5017fig2mag.jpg)
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Figure 2
The crystal structure of YncD reveals structural homology to the distantly related transporter FecA. (a) The crystal structure of YncD shown as a cartoon representation with rainbow coloring from the N-terminus (blue) to the C-terminus (red). Selected loops are labeled for reference. i.e. L3 = loop 3. The outer membrane-embedded region is boxed and labeled `OM'. A Ca2+ ion and a βOG detergent molecule that co-crystallized with YncD are shown as a sphere and in stick representation, respectively. (b) The crystal structure of YncD with the barrel domain shown as a cutaway surface and a stick representation and the plug domain shown as a cartoon representation. The labile section of the plug domain hypothesized to be displaced by TonB is shown in blue (Hickman et al., 2017  ), including the TonB box, which is disordered in the structure. (c) The extracellular loops of YncD, FecA (PDB entry 1kmp; Ferguson et al., 2002) and FhuE (PDB entry 6e4v; Grinter & Lithgow, 2019a) shown as a cartoon representation, with rainbow coloring and the same orientation as the top-down 90° rotated view in (a). |
![[Figure 2]](jb5017fig2.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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