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![[Figure 2]](ni5006fig2mag.jpg)
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Figure 2
Structure of the PATZ1 BTB domain. (a) Crystal structure of the BTB domain of the mouse PATZ1 protein (PDB entry 6guv) in cartoon representation (front view). The crystallographic asymmetric unit contains a PATZ1 BTB domain monomer (blue) with a second monomer (green) created by crystallographic symmetry. Secondary structures are indicated in capital and Greek letters. (b) Top view of the mouse PATZ1 BTB domain structure. N- and C-termini are indicated on one monomer. The coordinates of 31 residues in a central region, unique to mammalian PATZ1 BTB domains, could not be assigned (indicated by a dotted loop). (c) Crystal structure of the BTB domain of the zebrafish PATZ1 protein (PDB entry 6guw) with individual monomers coloured yellow and red (front view). (d) Top view of the zebrafish PATZ1 BTB structure. The coordinates of seven residues in the zebrafish PATZ1 BTB domain could not be assigned (indicated by a dotted loop). (e) Superimposition of the mouse (blue and green) and zebrafish (yellow and red) PATZ1 BTB domains (r.m.s.d. of 0.62 Å). (f) A space-filling representation of the mouse PATZ1 BTB domain structure. The predicted structure (in purple) of the central region was generated by homology modelling followed by conformation equilibration using MD simulations. Note that the modelled structure contains a predicted short β-strand. The three conserved degron residues, annotated at the bottom of Fig. 1 ![[link]](../../../../../../logos/arrows/d_arr.gif) (b) and predicted to play a role in BTB dimer degradation, are highlighted in red. Numbering refers to the residues in the crystal structure. |
![[Figure 2]](ni5006fig2.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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