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![[Figure 7]](qh5064fig7mag.jpg)
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Figure 7
Catalytic residues of MATα1 and mutation sites causing IPH. (a) Two active sites of MATα2 are shown with SAMe and PPNP molecules. Residues involved in catalysis are shown as green spheres. Missense mutations causing hypermethioninemia are shown as yellow spheres. Red spheres represent residues that are involved in both catalysis and missense mutations causing hypermethioninemia. (b) Missense mutations causing hypermethioninemia are shown as yellow spheres. The two subunits are shown in dark and light blue using the MATα2 structure (PDB entry 5a1i; Murray et al., 2016  ) as a model. (c, d) The Arg299 (c) and Arg356 (d) interaction sites are illustrated. Black dotted lines indicate hydrogen bonds and the interacting residues are shown as sticks. |
![[Figure 7]](qh5064fig7.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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