Figure 1
GLIC bound to the monocarboxylic acids acetate and propionate. (a) The acetate-binding pockets of the GLIC crystal structure (PDB entry 4hfi; Sauguet, Poitevin et al., 2013), shown in a detailed view with the intersubunit pocket on the left and the intrasubunit pocket on the right (acetate molecules in green-coloured stick representation). Five such pairs of intersubunit and intrasubunit sites are present in the GLIC homopentamer. (b) Similar view of a propionate-bound GLIC crystal structure, showing that propionate molecules (pink) are present in the same intersubunit and intrasubunit sites in GLIC. Note the similar protein conformation in (a) and (b). |