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Figure 1
GLIC bound to the monocarboxylic acids acetate and propionate. (a) The acetate-binding pockets of the GLIC crystal structure (PDB entry 4hfi; Sauguet, Poitevin et al., 2013BB17), shown in a detailed view with the intersubunit pocket on the left and the intrasubunit pocket on the right (acetate molecules in green-coloured stick representation). Five such pairs of intersubunit and intrasubunit sites are present in the GLIC homopentamer. (b) Similar view of a propionate-bound GLIC crystal structure, showing that propionate molecules (pink) are present in the same intersubunit and intrasubunit sites in GLIC. Note the similar protein conformation in (a) and (b).

Journal logoSTRUCTURAL
ISSN: 2059-7983
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