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Figure 2
GLIC crystal structures with dicarboxylates: succinate (a), malonate (b) and glutarate (c). (a) Detailed view of the succinate-bound GLIC structure, showing both intersubunit (left) and intrasubunit sites occupied by succinate molecules (purple sticks). (b, c) Similar views of the carboxylate-binding pockets in crystal structures of GLIC in complex with malonate (b) and glutarate (c). Only the intersubunit site is occupied by a molecule of malonate (pink) or glutarate (dark yellow). The intrasubunit pocket is occupied by a chloride ion (green sphere) in both cases. The 2FoFc density contoured at 2 Å around the ligands is coloured blue and contoured at 1σ.

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ISSN: 2059-7983
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