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Figure 5
The intrasubunit site in other pLGICs. (a) Superimposition of the binding pose of succinate (blue sticks, blue surface) in the intrasubunit site of GLIC with those of flurazepam in ELIC (PDB entry 2yoe; Spurny et al., 2012BB19) coloured tan and bromocinnamic acid in sTeLIC (PDB entry 6fli; Hu et al., 2018BB9) coloured pink. (b) The succinate binding pose in GLIC superimposed on the intrasubunit pocket of the α4β2 acetylcholine receptor (PDB code 5kxi; Morales-Perez et al., 2016BB36). The surface representation was generated with UCSF Chimera.

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