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![[Figure 1]](nw5103fig1mag.jpg)
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Figure 1
TLR signaling and domain organization of TLR8. (a) Overview of TLR ligand and signaling pathways. All TLRs except for TLR3 transduce signals through the MyD88-dependent pathway, and TLR3 and TLR4 transduce signals through a TRIF-dependent pathway, activating transcription factors such as NF-κB, AP-1, IRF3 or IRF7. Finally, TLR signaling induces inflammatory cytokines or interferons. (b) Schematic representation of TLR8. The ectodomain of TLR8 consists of 26 LRRs and the N-terminal and the C-terminal regions. A characteristic loop, the Z-loop, is inserted between LRR14 and LRR15. A single transmembrane helix and the TIR domain are located on the C-terminus. |
![[Figure 1]](nw5103fig1.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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