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Figure 4
Illustration of the unliganded state and the ligand-induced activated and inactivated states of TLR8. TLR8 forms a dimeric structure without ligands. Agonist binding causes rearrangement of TLR8 into the activated structure. The antagonists fix and stabilize the inactivated structure, which prevents agonists from binding to TLR8. In the illustration the ligands are shown to be present on the TLR8 dimers, but in actuality they are sandwiched between the two protomers.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 76| Part 7| July 2020| Pages 621-629
https://doi.org/10.1107/S2059798320006518
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