Targeting the innate immune receptor TLR8 using small-molecule agents

Sakaniwa, K.; Shimizu, T.

doi:10.1107/S2059798320006518

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 6
Application for disease treatment. The agonists are mainly used as adjuvants to augment immune responses to cancer or infection. Antagonists are used to suppress aberrant immune responses owing to autoimmunity. Structural characterization helps to develop and to improve the drug candidates.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 76| Part 7| July 2020| Pages 621-629

https://doi.org/10.1107/S2059798320006518

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