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Figure 5
CYRI-B and CYFIP1 present a high degree of structural similarity. (a) Side-by-side view of the CYRI-B (left) and CYFIP1 DUF1394 domain (PDB entry 3p8c; right) structures. The colour code of CYRI-B is as in Fig. 1[link]. The presence of an extra hairpin in CYFIP1 is indicated. (b) Secondary-structure alignment of the N-terminal (green), medial (yellow) and C-terminal (blue) subdomains of the two proteins. The r.m.s.d. value and number of Cα atoms are shown beside each alignment (from SUPERPOSE; Krissinel & Henrick, 2004BB25). (c) Top, overall structure of the WAVE regulatory complex (WRC; PDB entry 3p8c). The DUF1394 domain of CYFIP1 is coloured as in (a). Bottom left, close-up view of the 304–314 hairpin of CYFIP1 showing residues involved in hydrogen-bond interactions with the rest of the protein (grey). Bottom right, superposition of CYRI-B on the DUF1394 domain of CYFIP1 showing the absence of the 304–314 hairpin. An asterisk indicates a steric clash.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 76| Part 10| October 2020| Pages 1015-1024
https://doi.org/10.1107/S2059798320010906
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