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![[Figure 2]](nj5292fig2mag.jpg)
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Figure 2
Met CXCL13 crystal structure compared with that of a canonical C-X-C chemokine. Data-collection and refinement statistics are shown in Table 1 ![[link]](../../../../../../logos/arrows/d_arr.gif) and structural features are labeled. (a) Met CXCL13 crystallizes in space group P3121 with one monomer in the asymmetric unit. Disulfide bonds are depicted in red. (b) As a representative example, a monomer of CXCL12 (from PDB entry 2nwg; Murphy et al., 2007) is shown. Disulfide bonds are depicted in orange. (c) The Met CXCL13 structure contains one monomer in the asymmetric unit, but a symmetry mate shows that a dimer is formed between the unique β0 strands, allowing an overall eight-stranded unit to be seen. (d) CXCL12 is once again used as a comparison to demonstrate how C-X-C chemokines typically dimerize via the β1 strands in the core domain, leading to an overall six-stranded unit. |
![[Figure 2]](nj5292fig2.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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