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![[Figure 6]](nj5292fig6mag.jpg)
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Figure 6
Comparisons between the Met and Δ1L2M CXCL13 crystal structures and the structures of CXCL13 found in PDB entries 5cba and 5cbe. Structural features are labeled. (a) The core domain from the Met CXCL13 structure (blue) and chain E of the Δ1L2M CXCL13 structure (gray) were overlaid with those from PDB entries 5cba (shades of green) and 5cbe (orange and yellow). The core domain exhibits relative rigidity between the structures (see Supplementary Fig. S4 for calculated r.m.s.d. values). Note that the β0 strand localized in the N-loop only occurs in the Δ1L2M CXCL13 monomer. (b) Close-up view of the change in the angling of the α1 helix in the structures with PDB codes 5cba and 5cbe. As a representative for each α1 helix position, the Met CXCL13 monomer was compared with one of the monomers (chain F) of PDB entry 5cbe. The angle between the two helical positions was found to be approximately 11.4°. (c) N-terminal trajectories between the structures of Met CXCL13, Δ1L2M CXCL13 and PDB entries 5cba and 5cbe. Note that only chain E of the Δ1L2M CXCL13 structure was used for clarity and that β−1 only occurs in this structure. |
![[Figure 6]](nj5292fig6.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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