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![[Figure 7]](nj5292fig7mag.jpg)
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Figure 7
Comparisons between the Met and Δ1L2M CXCL13 crystal structures and the structures of murine CXCL13 found in PDB entries 5l7m and 5izb. Structural features are labeled. (a) Alignment of human and murine CXCL13. Asterisks denote amino-acid identity, whereas periods and colons indicate low and high similarity, respectively. (b) Alignment of the core domains of the Met and Δ1L2M CXCL13 structures (blue and shades of gray, respectively) with that of the ensemble of WT mCXCL13 atomic positions (red). (c) Alignment of the core domain of Met CXCL13 (blue) with that of the ensemble of Met mCXCL13 atomic positions (brown). (d) Alignment of the Met CXCL13 structure (blue) with that of the N-terminal atomic positions of Met mCXCL13 (brown). (e) Alignment of the Met CXCL13 structure (blue) with that of chain E of the Δ1L2M CXCL13 structure (gray) and the N-terminal atomic positions of WT mCXCL13 (red). (f) Left: alignment of the Met and Δ1L2M CXCL13 structures minus their N-termini (blue and shades of gray, respectively) with the atomic positions of the C-terminal extension of WT mCXCL13 (red). Right: alignment of the Met CXCL13 structure minus its N-terminus (blue) with the atomic positions of the C-terminal extension of Met mCXCL13 (brown). |
![[Figure 7]](nj5292fig7.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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