Figure 4
(a) Newly identified hits for JMJD2DA showing PanDDA maps as displayed in Fig. 2 labelled with the data-set name and the cluster of which it was a member. (b) Left, x377, cluster A from the unpartitioned PanDDA analysis, present but not easily interpretable; right, x377, cluster A density using pre-clustering, now easily identifiable as the ligand. (a) and (b) were rendered in Coot (Emsley et al., 2010). (c) Total signal from the PanDDA event map, plotted for all data sets shared between the unpartitioned (blue) and pre-clustered (orange) points, ordered by the pre-clustered total signal. All lines are drawn as visual guides to show the change in signal per data set. |