Figure 2
Crystal structures. (a) PNA in complex with the N-linked glycoclusters NGS, diNGS and diNGT. (b) PNA in complex with the S-linked glycoclusters STG, STGD and diSTGD. The four PNA subunits observed in the quaternary assembly are denoted in cartoon representation in different colors. The glycocluster molecules bound to the subunits are represented as black sticks. Only the ligand portions defined by the electron-density maps are shown. Magenta and green spheres represent Mn2+ and Ca2+ ions, respectively. (c) Inset highlighting the sugar-binding site. The four enclosed loops are labeled and illustrated in different colors. |