Flipping the substrate preference of Hazara virus ovarian tumour domain protease through structure-based mutagenesis

Dzimianski, J.V.; Mace, S.L.; Williams, I.L.; Freitas, B.T.; Pegan, S.D.

doi:10.1107/S2059798320012875

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 4
Altering the enzymatic activity of HAZV OTU. (a) Structure of the HAZV OTU–Ub complex, with residues targeted for mutation indicated with red dots. (b, c) Activity of HAZV OTU mutants towards Ub-AMC and ISG15-AMC, respectively.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 76| Part 11| November 2020| Pages 1114-1123

https://doi.org/10.1107/S2059798320012875

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