Figure 2
CD spectra of the Hpar-18 oligonucleotide, indicating the presence of G-quadruplex structures in equilibrium with other conformational species. (a) Hpar-18 at a concentration of 20 µM in various solutions compared with Hpar-22, a 22-mer consisting of the Hpar-18 sequence preceded by the RAYT-recognizing tetranucleotide GTAG. Hpar-22 data are from Charnavets et al. (2015). (b) Hpar-18 in PBS with various concentrations of Sr2+. |