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![[Figure 3]](cb5122fig3mag.jpg)
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Figure 3
DNA 18-mer structures with two central T–T noncanonical (mismatched) base pairs. (a) The duplex of Chom-18 (PDB entry 6ros) with DNA strands in blue and red and Sr2+ cations in green. (b) DNA region G1–G4 and the complementary region C15–C18 from a symmetry-related chain. The anomalous Fourier map is shown as a gray mesh and is contoured at the 1.5σ level for Chom-18Br (PDB entry 6ror). (c) DNA region G5–T9 and the complementary region T10–C14 with poor observed (2mFo − DFc) electron density contoured at the 1.0σ level for Chom-18 (PDB entry 6ros). (d) The packing of duplexes in PDB entries 6ror, 6ros and 6rou. All contacts shorter than 3.6 Å between the asymmetric unit strand (red) and the symmetry-related duplex (G1*, blue; C18**, green) are shown. (e) The central T–T mismatches. Sr2+ at the twofold axis binds to T9 and the symmetry-related T9*, as shown for Chom-18 (PDB entry 6ros). |
![[Figure 3]](cb5122fig3.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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