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![[Figure 3]](nz5001fig3mag.jpg)
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Figure 3
(a) DC479 (depicted in stick representation, pink) incorporated into the binding site of CRABPII (ribbon representation, dark blue; O atoms, red; N atoms, blue). The key binding resides (Arg112-Arg133-Tyr135) and a conserved water molecule can be seen at the base of the hydrophobic pocket with predicted hydrogen bonds to the ligand (dark blue; O atoms, red; N atoms, blue). NLS-forming residues (white; N atoms, blue) can be seen facing externally on the left. The protein forms a dimer with noncrystallographic symmetry, of which chain A is displayed for clarity. The r.m.s.d. between chains A and B on Cα atoms is 0.23 Å. (b) Ligand density of DC479 in chain A in the ligand-binding site of CRABPI (2Fo − Fc map including ligand, contour σ = 1.50). (c) Chemical structure of DC479. |
![[Figure 3]](nz5001fig3.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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