Figure 2
Comparative views of SARS-CoV and SARS-CoV-2 E protein models derived from NMR data. The top panel shows the lowest-energy NMR-derived structural model of the SARS-CoV E protein homopentamer (PDB entry 5x29; Surya et al., 2018) in a lateral view (a) and an end-on view (b). The bottom panel shows an NMR-derived model of the SARS-CoV-2 E protein (PDB entry 7k3g; Mandala et al., 2020) in lateral (c) and end-on (d) views. Notice that the ion-channel-lining helices of the SARS-CoV E protein are more perpendicular to the membrane plane compared with those of the SARS-CoV E protein. Images were produced using CCP4mg (McNicholas et al., 2011). |