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![[Figure 4]](ud5019fig4mag.jpg)
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Figure 4
The C-terminal loop dictates the conformation of the 5′ RNA region. (a) Superposition of Prp2 and Prp43 in the pre-catalytic state via the helicase core. The 3′ stacked RNA region superposes almost identically, but at the beginning of the 5′ region the RNA bound to Prp43 interacts with the C-terminal loop. This loop has a different conformation in Prp2 and does not interact with the RNA. (b) The base of the first nucleotide of the 5′ RNA region interacts with a proline and a serine of the Prp43 C-terminal loop. (c) The alternative conformation of the Prp2 C-terminal loop is stabilized by interactions with surrounding residues belonging to the helix-bundle domain and the hook-loop of the RecA2 domain. |
![[Figure 4]](ud5019fig4.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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