Figure 4
Cartoon representation of the superposition of the c-Src SH3 domain (PDB entry 6xvn; chain A, purple; chain B, cyan) and (a) the v-Src SH3 N117D-V124L variant (PDB entry 7nes) and (b) the v-Src SH3 Q128R variant (PDB entry 7ner). In both chains of the c-Src SH3 domain, the n-Src loop has been partially modelled and the unmodelled residues are represented by a dashed line. Hydrogen bonds in the RT loop of (c) the v-Src SH3 N117D-V124L variant, (d) the v-Src SH3 Q128R variant and (e) the c-Src SH3 domain (chain A). |