The impact of oncogenic mutations of the viral Src kinase on the structure and stability of the SH3 domain

Salinas-Garcia, M.C.; Plaza-Garrido, M.; Camara-Artigas, A.

doi:10.1107/S2059798321004344

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 8
Superposition of the (a) v-Src SH3 Q128R (green) and (b) v-Src SH3 N117D-V124L (yellow) variants with the structure of the c-Src SH3 Q128R–APP12 complex (PDB entry 5ob1). The SH3 domain is represented as a cartoon (white) and the peptide as sticks (magenta). The mutations present in each oncogenic variant are represented as sticks. The Asp99–APP12–Arg7 salt bridge that drives the peptide orientation upon binding is also shown.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 77| Part 6| June 2021| Pages 854-866

https://doi.org/10.1107/S2059798321004344

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