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![[Figure 6]](jc5035fig6mag.jpg)
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Figure 6
Three-domain structure of Sc-Rsm22. (a) The ab initio dummy-atom model of monomeric Sc-Rsm22 aligned with the truncated Tb-Rsm22 cryo-EM structure including the SAM-MTase domain (extended loop regions have been removed) and the OB-motif of the C-terminal domain. The zinc-finger motif of the SAM-MTase domain, corresponding to the region Lys126–Lys461 in Sc-Rsm22, is included in this structural model of Sc-Rsm22. The hypothesis is that the SAM-MTase core fold is located in the middle of the elongated solution structure extended by the unknown N-terminal and potential OB-fold C-terminal structures. (b) The ab initio dummy-atom model of monomeric Sc-Rsm22 aligned with full-length Tb-Rsm22. The N- and C-termini of the Tb-Rsm22 cryo-EM structure, as well as part of the extended loop regions (655–784) (see Fig. 1 ![[link]](../../../../../../logos/arrows/d_arr.gif) b), are highlighted in (b). (c) A fitting curve of the full-length Tb-Rsm22 coordinates [the same as used in (b)] against the experimental SAXS data. |
![[Figure 6]](jc5035fig6.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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