|
Figure 2
PA binding to the FA-binding site of hFABP7. (a) 2Fo − Fc electron-density map (gray mesh, 1.2σ) of PA bound to hFABP7. (b) Surface representation of hFABP7. PA is not observed at the fatty acid inlet due to the closed conformation of the cap domain. PA is partially observed in the 3 Å inner diameter hole between the β5 and β6 strands. (c) Electrostatic surface structure of the FA-binding pocket. (d) Entrance of the FA-binding site of hFABP7 excluding the cap domain. (e) Interactions between PA and amino acids within the PA-binding pocket of hFABP7. |