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Figure 8
β-Links in proteases of SCOPe superfamily b.47.1. (a) Bovine trypsin (PDB entry 1bty; Katz et al., 1995BB24). Backbone plot with the β-link, associated classic β-bulge and active-site residues (labelled and side chains shown) coloured CPK, adjacent residues salmon pink and other parts of the protein white. (b) (i) Human prokallikrein 6 (PDB entry 1gvl chain A; Gomis-Rüth et al., 2002BB17). (ii) Human kallikrein 6 (PDB entry 1l2e chain A; Bernett et al., 2002BB3). Shown is the region near the catalytic Ser195. The arrowheads indicate the position of the hydrogen bond in the β-turn of the β-link found only in the active protein. Side chains are shown for Ser195, Asp194 and residues in proximity to the latter. Leu16 is not shown in (i) because it is distal to the residues shown before the activation of prokallikrein. (c) Human SARS-CoV-2 Mpro (PDB entry 7bqy; Jin et al., 2020BB23). The environment of the β-link with the side chains of the active-site Cys145, His163 and His41 is shown.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
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