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![[Figure 7]](ni5011fig7mag.jpg)
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Figure 7
Modes of inactivation for OmpR/PhoB response regulators. (a) Inactive conformations of four different response regulators are shown, compared with the inactive conformation of VanRSc. For the inactive response regulators, the receiver domains are shown in yellow, the DNA-binding domains in dark blue and the recognition helix α8 in hot pink. The activated VanRSc structure is also shown for the sake of comparison, with the receiver domain colored cyan. This panel was inspired by a figure in Friedland et al. (2007  ). PDB codes are as follows: MtrA, 2gwr; PrrA, 1ys6; DrrB, 1p2f; DrrD, 1kgs. (b) In the inactive VanRSc structure, the interdomain interaction involves the insertion of the β6–β7 turn from the DNA-binding domain into a cleft between helices α2 and α3 of the receiver domain, placing Phe137 into a hydrophobic pocket formed by Leu37, Leu40 and Ile66. (c) In the activated VanRSc structure a similar interdomain interaction is also formed, despite a change in the relative orientations of the two domains. |
![[Figure 7]](ni5011fig7.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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