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Figure 3
Structure and binding pocket of PaHSS. (a) Cartoon representation of PaHSS (PDB entry 6y87 chain A) with the NAD(P)-binding Rossmann-like domain colored yellow (residues 1–155 and 389–419) and the HSS-like domain in blue (residues 156–388 and 420–469). The solvent-accessible surface of the binding pocket is depicted in transparent red with the entrance pointing upwards. The NAD+ molecule lining the surface of the pocket is shown in ball-and-stick representation. (b) The solvent-accessible surface of the binding pocket was rotated by an angle of ∼90° around the y axis in relation to (a). Selected side chains lining the pocket surface, the NAD+ molecule and the PUT molecule within the active site are depicted in ball-and-stick representation.

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ISSN: 2059-7983
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