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![[Figure 2]](jb5028fig2mag.jpg)
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Figure 2
Iodotyrosines in bovine Tg. Side chains and cryoEM map density fit for thyroxinated side chains at Tyr24 (a) and Tyr2575 (b). Map contour level 0.032. (c) Compared with the human Tg structure (gray; PDB entry 6scj; Coscia et al., 2020  ) with non-iodinated tyrosine side chains at Tyr2573 and Tyr2540 (Tyr2575 and Tyr2542 in bovine Tg), in the bovine Tg structure (red) the α-helix containing the donor Tyr2542 has unwound and is shifted 7 Å away from the thyroxine pocket. (d) Tyr24 and Tyr149 in the bovine Tg structure (red) assume similar positions compared with the human Tg structure (gray), although the relative dispositions of the tyrosines and the conformations of the amino-terminal peptide containing the acceptor Tyr24 differ substantially. |
![[Figure 2]](jb5028fig2.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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