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Figure 3
Proposed mechanisms for the coupling of diiodotyrosine side chains at two distinctive sites of Tg. (a) The amino-terminal loop (purple) that contains Tyr24 (green) swings by Tyr149 (yellow), where the two rings are coupled to form thyroxine at Tyr24. (b) The α-helices that contain Tyr2575 (green) and Tyr2542 (yellow) are brought together to form thyroxine at Tyr2575, and the second helix is displaced to form the binding pocket for T4 at Tyr2575.

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ISSN: 2059-7983
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