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Figure 1
Crystallization chemical space, represented here by blue rectangles, is a large space. Every (crystallizable) protein will have one or more success regions within that space that supports the formation of crystals; these are represented by colored circles within the blue rectangles. If many proteins crystallize in the same part of crystallization space this would be a general crystallization `hotspot' and might be a good place to start a new crystallization campaign. The current study tries to find the overlap between two diverse spaces: protein space and chemical space. These diagrams are cartoons: the dark hotspots show overlap from only two proteins, and the success regions are probably asymmetrical and of course are much smaller than the whole chemical space.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
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