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Figure 1
Crystallization chemical space, represented here by blue rectangles, is a large space. Every (crystallizable) protein will have one or more success regions within that space that supports the formation of crystals; these are represented by colored circles within the blue rectangles. If many proteins crystallize in the same part of crystallization space this would be a general crystallization `hotspot' and might be a good place to start a new crystallization campaign. The current study tries to find the overlap between two diverse spaces: protein space and chemical space. These diagrams are cartoons: the dark hotspots show overlap from only two proteins, and the success regions are probably asymmetrical and of course are much smaller than the whole chemical space. |