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![[Figure 3]](id5011fig3mag.jpg)
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Figure 3
Incorporation of prior information in real space. (a) Macromolecular density is positive definite, which provides a substantial restraint. (b) The densities of protein and nucleic acids are known, and such information can be incorporated into cryo-EM real-space processing as a real-space prior. (c) Macromolecules are composed of either sample or solvent, allowing binary restraints leading on from existing masking approaches. (d) For single-particle analysis, connectivity can be assumed and provides a further restraint, which is already partially utilized in real space. |
![[Figure 3]](id5011fig3.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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