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Figure 1
SARS-CoV-2 Mpro architecture, free form (PDB entry 6y2e). (a) Dimeric assembly of the protease with the main structural features discussed in the text highlighted. Protomer A is in blue-based colors and protomer B is in yellow/red-based colors. The two oxyanion loops and the two catalytic cysteines 145 are shown in green. (b) Comparison between different oxyanion-loop conformations of Mpro: active in SARS-CoV-2 Mpro (PDB entry 6y2e) in pink, collapsed-inactive in SARS-CoV Mpro (PDB entry 1uj1 chain B) in magenta and new-inactive in SARS-CoV-2 Mpro (this work) in green.

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