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Figure 7
Dimeric architecture of new-inactive Mpro. (a) The new conformation of the oxyanion loop (labeled `loop') causes changes in the interface between protomer A (blue) and protomer B (light blue) at the level of the N-­finger (labelled `NF') and the C-terminal tail (labeled `C-term'). (b) Local differences between the new structure [blue-based colors as in (a)] and the canonical structure (PDB entry 6y2e; brown-based colors, with intact C-terminus): the shift of the Leu141 side chain seems to have major effects in destabilizing the C-terminal tail of the new structure.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 78| Part 3| March 2022| Pages 363-378
https://doi.org/10.1107/S2059798322000948
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