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Figure 9
Details of the putative interaction between new-inactive Mpro (green) and the C-terminal acyl-intermediate peptide substrate from PDB entry 7khp (orange). Hydrogen bonds between the substrate and the binding site are depicted as dashed black lines. Aside from the P1 glutamine and its interactions with the P1 pocket, other common interaction features such as hydrogen bonds to Glu166 and Gln189 and hydrophobic interactions of the P2 phenylalanine side chain within the S2 subpocket are retained.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 78| Part 3| March 2022| Pages 363-378
https://doi.org/10.1107/S2059798322000948
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