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Figure 4
Binding of avadomide to MsCI4. (a) Chemical drawings of thalidomide and avadomide. (b) Cartoon representation of MsCI4 in complex with avadomide, highlighting the tryptophans of the aromatic cage and the structural zinc ion. (c) Interactions within the binding pocket, with the binding pose of thalidomide superposed in purple (PDB entry 4v2y), highlighting the additional interaction of the amine with Glu76. (d) FoFc omit maps of thalidomide (chains A and B) and avadomide (chain C) at a contour level of 1.5σ. As generally observed for the phthaloyl moiety of thalidomide, the distal parts of the protruding quinazolinone moiety are less defined in the electron density.

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ISSN: 2059-7983
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