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Figure 5
Binding of iberdomide to MsCI4. (a) Superposition of chains A, B and C, showing differences in the protruding moieties of iberdomide. (b) Coloured surface representation of MsCI4 showing the residue conservation between MsCI4 and hTBD, according to the sequence alignment depicted in Fig. 6[link]. (c) Superposed structures of MsCI4–iberdomide, hCRBN–iberdomide (PDB entry 5v3o, iberdomide in green) and hCRBN–pomalidomide–IKZF1 (PDB entry 6h0f) showing the possible compatibility of alternative binding modes of iberdomide with the binding of the neo-substrate IKZF1. (d, e, f) Interactions of iberdomide within the different chains, with iberdomide from PDB entry 5v3o superposed in green. FoFc omit maps are shown with the indicated contour levels. On the right, the binding poses of iberdomide are shown with the protein surface coloured according to amino-acid chemistry, coloured by atom type.

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ISSN: 2059-7983
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