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Figure 6
Sequence conservation of MsCI4 and human CRBN. Sequence conservation according to the sequence alignment of hTBD with wild-type (WT) MsCI4 and humanized MsCI4 is mapped onto the surface of MsCI4. Identical residues are shown in dark orange in the surface representation and marked with `|' in the sequence alignment; similar residues are shown in light orange and highlighted with `:'. Mutations introduced in the humanized MsCI4 construct are marked with `*'. The superposition of effector-bound MsCI4 structures at the top left includes PDB entries 4v2y, 4v30, 4v31, 5oh1, 5oh3, 5oh8, 6r0s, 6r0v, 6r11, 6r12, 6r18, 6r19, 6r1a, 6r1c, 6r1d, 6r1k, 6r1w and 6r1x. The structure at the top right shows the previously published humanized MsCI4 construct in complex with the hydrolyzed thalidomide molecule α-(2-carboxybenzamido)glutarimide (PDB entry 6r0q).

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ISSN: 2059-7983
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